Brand name: methotrexate
Generic name: Rheumatrex, Methoblastin, amethopterin, Emthexate, MTX

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He was treated for RA with infliximab (3 mg/kg) for 3 years, as well as methotrexate (20 mg/week), and corticosteroids. His only other medications were amlodipine (5 mg per day) and methotrexate (15 mg per week). Such patients require especially careful monitoring for toxicity, and require dose reduction or, in some cases, discontinuation of methotrexate administration. However, elderly patients are more likely to have age-related renal function impairment, which may require adjustment of dosage in patients receiving leucovorin as a rescue from the effects of high-dose methotrexate. Methotrexate, especially at higher doses or with prolonged treatment, has been associated with hepatotoxicity including acute hepatitis, chronic fibrosis, necrosis, cirrhosis, and liver enzyme elevations. Methotrexate has been reported to cause fetal death and/or congenital anomalies. This indicates that NSAIDs may enhance the toxicity of methotrexate. Necrotizing fasciitis resulting in death has been reported in a 54-year-old man with rheumatoid arthritis receiving infliximab every 8 weeks along with intramuscular methotrexate weekly dosage.

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